Unfortunately, the concentration of Halichondrin B in the sea sponge wasn enough to enable commercial production for use in chemotherapy. For example, a ton of sea sponges could only produce 300 mg of Halichondrin B! The race was on to try to synthesise Halichondrin B in the lab, which wasn’t easy due to its large size (molecular weight 1110) and complex structure. Aicher and coworkers, chemists at Harvard University, published the complete chemical synthesis of this molecule..
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